William E. Kraus, MD

Professor of Medicine
Professor in the School of Nursing
Department / Division:
Medicine / Medicine - Cardiology
DUMC 3327
Durham, NC 27710
Appointment Telephone:
Office Telephone:
  • MD, Duke University School of Medicine, 1982
  • Internal Medicine, Duke University Medical Center, 1983-1986
  • Cardiology, Duke University Medical Center, 1986-1988
Other Training:
  • Fellow, American College of Cardiology
  • Fellow, American Heart Association
  • Fellow, American College of Sports Medicine
Clinical Interests:
Cardiac rehabilitation and prevention; congestive heart failure; exercise physiology; genetics of cardiovascular disease; coronary heart disease
Representative Publications:
  • Connelly, JJ; Wang, T; Cox, JE; Haynes, C; Wang, L; Shah, SH; Crosslin, DR; Hale, AB; Nelson, S; Crossman, DC; Granger, CB; Haines, JL; Jones, CJ; Vance, JM; Goldschmidt-Clermont, PJ; Kraus, WE; Hauser, ER; Gregory, SG. GATA2 is associated with familial early-onset coronary artery disease. PLoS Genetics. 2006;2:e139.  Abstract
  • Huffman, KM; Samsa, GP; Slentz, CA; Duscha, BD; Johnson, JL; Bales, CW; Tanner, CJ; Houmard, JA; Kraus, WE. Response of high-sensitivity C-reactive protein to exercise training in an at-risk population. American Heart Journal. 2006;152:793-800.  Abstract
  • Duscha, BD; Slentz, CA; Johnson, JL; Houmard, JA; Bensimhon, DR; Knetzger, KJ; Kraus, WE. Effects of exercise training amount and intensity on peak oxygen consumption in middle-age men and women at risk for cardiovascular disease. Chest. 2005;128:2788-2793.  Abstract
  • Hittel, DS; Kraus, WE; Tanner, CJ; Houmard, JA; Hoffman, EP. Exercise training increases electron and substrate shuttling proteins in muscle of overweight men and women with the metabolic syndrome. Journal of Applied Physiology. 2005;98:168-179.  Abstract
  • Slentz, CA; Aiken, LB; Houmard, JA; Bales, CW; Johnson, JL; Tanner, CJ; Duscha, BD; Kraus, WE. Inactivity, exercise, and visceral fat. STRRIDE: a randomized, controlled study of exercise intensity and amount. Journal of Applied Physiology. 2005;99:1613-1618.  Abstract
  • Hauser, ER; Crossman, DC; Granger, CB; Haines, JL; Jones, CJ; Mooser, V; McAdam, B; Winkelmann, BR; Wiseman, AH; Muhlestein, JB; Bartel, AG; Dennis, CA; Dowdy, E; Estabrooks, S; Eggleston, K; Francis, S; Roche, K; Clevenger, PW; Huang, L; Pedersen, B; Shah, S; Schmidt, S; Haynes, C; West, S; Asper, D; Booze, M; Sharma, S; Sundseth, S; Middleton, L; Roses, AD; Hauser, MA; Vance, JM; Pericak-Vance, MA; Kraus, WE. A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study. American Journal of Human Genetics. 2004;75:436-447.  Abstract
  • Houmard, JA; Tanner, CJ; Slentz, CA; Duscha, BD; McCartney, JS; Kraus, WE. Effect of the volume and intensity of exercise training on insulin sensitivity. Journal of Applied Physiology. 2004;96:101-106.  Abstract
  • Zhang, JS; Kraus, WE; Truskey, GA. Stretch-induced nitric oxide modulates mechanical properties of skeletal muscle cells. American Journal of Physiology: Cell Physiology. 2004;287:C292-C299.  Abstract
  • Duscha, BD; Annex, BH; Green, HJ; Pippen, AM; Kraus, WE. Deconditioning fails to explain peripheral skeletal muscle alterations in men with chronic heart failure. Journal of the American College of Cardiology. 2002;39:1170-1174.  Abstract
  • Kraus, WE; Houmard, JA; Duscha, BD; Knetzger, KJ; Wharton, MB; McCartney, JS; Bales, CW; Henes, S; Samsa, GP; Otvos, JD; Kulkarni, KR; Slentz, CA. Effects of the amount and intensity of exercise on plasma lipoproteins. New England Journal of Medicine. 2002;347:1483-1492.  Abstract
  • Muoio, DM; MacLean, PS; Lang, DB; Li, S; Houmard, JA; Way, JM; Winegar, DA; Corton, JC; Dohm, GL; Kraus, WE. Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. Journal of Biological Chemistry. 2002;277:26089-26097.  Abstract
  • Muoio, DM; Way, JM; Tanner, CJ; Winegar, DA; Kliewer, SA; Houmard, JA; Kraus, WE; Dohm, GL. Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells. Diabetes. 2002;51:901-909.  Abstract
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