Sudha Kaup Shenoy, PhD

Associate Professor of Medicine
Assistant Professor in Cell Biology
Department / Division:
Medicine / Medicine - Cardiology
412 Sands Bldg
Durham, NC 27710
Office Telephone:
(919) 681-5061
  • PhD, Oklahoma State University at Stillwater, 1998
Representative Publications:
  • Shenoy, SK; Han, S; Zhao, YL; Hara, MR; Oliver, T; Cao, Y; Dewhirst, MW. ß-arrestin1 mediates metastatic growth of breast cancer cells by facilitating HIF-1-dependent VEGF expression. Oncogene: Including Oncogene Reviews. 2012;31:282-292.  Abstract
  • Shenoy, SK. ß-arrestin-biased signaling by the ß-adrenergic receptors. Current Topis in Membranes. 2011;67:51-78.  Abstract
  • Xiao, K; Shenoy, SK. Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains. The Journal of biological chemistry. 2011;286:12785-12795.  Abstract
  • Berthouze, M; Venkataramanan, V; Li, Y; Shenoy, SK. The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. EMBO Journal. 2009;28:1684-1696.  Abstract
  • Shenoy, SK; Modi, AS; Shukla, AK; Xiao, K; Berthouze, M; Ahn, S; Wilkinson, KD; Miller, WE; Lefkowitz, RJ. Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proceedings of the National Academy of Sciences of USA. 2009;106:6650-6655.  Abstract
  • Shenoy, SK; Xiao, K; Venkataramanan, V; Snyder, PM; Freedman, NJ; Weissman, AM. Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. The Journal of biological chemistry. 2008;283:22166-22176.  Abstract
  • DeWire, SM; Ahn, S; Lefkowitz, RJ; Shenoy, SK. Beta-arrestins and cell signaling. Annual Review of Physiology. 2007;69:483-510.  Abstract
  • Girnita, L; Shenoy, SK; Sehat, B; Vasilcanu, R; Vasilcanu, D; Girnita, A; Lefkowitz, RJ; Larsson, O. Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression. The Journal of biological chemistry. 2007;282:11329-11338.  Abstract
  • Shenoy, SK. Seven-transmembrane receptors and ubiquitination. Circulation Research. 2007;100:1142-1154.  Abstract
  • Shenoy, SK; Barak, LS; Xiao, K; Ahn, S; Berthouze, M; Shukla, AK; Luttrell, LM; Lefkowitz, RJ. Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation. The Journal of biological chemistry. 2007;282:29549-29562.  Abstract
  • Shenoy, SK; Drake, MT; Nelson, CD; Houtz, DA; Xiao, K; Madabushi, S; Reiter, E; Premont, RT; Lichtarge, O; Lefkowitz, RJ. beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. The Journal of biological chemistry. 2006;281:1261-1273.  Abstract
  • Lefkowitz, RJ; Shenoy, SK. Transduction of receptor signals by beta-arrestins. Science. 2005;308:512-517.  Abstract
  • Shenoy, SK; Lefkowitz, RJ. Angiotensin II-stimulated signaling through G proteins and beta-arrestin. Sciences STKE [electronic resource] : signal transduction knowledge environment. 2005;2005:cm14.  Abstract
  • Shenoy, SK; Lefkowitz, RJ. Receptor regulation: beta-arrestin moves up a notch. Nature Cell Biology. 2005;7:1159-1161.  Abstract
  • Shenoy, SK; Lefkowitz, RJ. Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. The Journal of biological chemistry. 2005;280:15315-15324.  Abstract
  • Shenoy, SK; Lefkowitz, RJ. Seven-transmembrane receptor signaling through beta-arrestin. Sciences STKE [electronic resource] : signal transduction knowledge environment. 2005;2005:cm10.  Abstract
  • Ge, L; Shenoy, SK; Lefkowitz, RJ; DeFea, K. Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2. The Journal of biological chemistry. 2004;279:55419-55424.  Abstract
  • Shenoy, SK; Lefkowitz, RJ. Resonating to the music of ubiquitination. Nature Methods. 2004;1:191-193.  Abstract
  • Martin, NP; Lefkowitz, RJ; Shenoy, SK. Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination. The Journal of biological chemistry. 2003;278:45954-45959.  Abstract
  • Shenoy, SK; Lefkowitz, RJ. Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling. The Biochemical journal. 2003;375:503-515.  Abstract
  • Shenoy, SK; Lefkowitz, RJ. Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. The Journal of biological chemistry. 2003;278:14498-14506.  Abstract
  • Shenoy, SK; McDonald, PH; Kohout, TA; Lefkowitz, RJ. Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science. 2001;294:1307-1313.  Abstract
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